Assalamualiakum wr. Wb
Salam pramuka!
Alhamdulillahirabbil alamin, kami panjatkan rasa Syukur kepada tuhan Yang Maha Esa, Allah SWT, karena atas kehendaknyalah salah satu agenda ekstrakulikuler Pramuka SDN Grogol Utara 03 dapat telaksana. Maksimal atau tidaknya itu menjadi penilaian masing-masing pihak. Tentu saja kami berupaya semampu kami agar agenda kemarin terlaksana dengan baik.
Baiklah.. kali ini kami ingin membagikan apa saja yang perlu diketahui tentang pelaksanaan peringatan HUT Pramuka ke – 63 kemarin. Yang pasti, tema besar HUT Pramuka tahun ini adalah “Berjiwa Pancasila Menjaga NKRI”. Rangkaian kegiatan yang sudah dilaksanakan semoga mengartikan bahwa tema ini telah diilhami oleh seluruh warga SDN Grogol Utara 03 saat itu juga ketika kita semua melakasanakannya. Tapi… besar harapan bahwa jiwa Pancasila ini tidak hanya berhenti disini, semoga tetap terus melekat pada diri kita masing-masing.
Jadi bagaimana hasil dari rangkaian kegiatan kemarin? Yuk kita bahas..
- Penggalangan bakti sosial
Seketika ruang serba guna disamping ruang guru penuh dengan bahan sembako. Kok bisa? Iyaa, itu berkat rasa kepedulian peserta didik SDN Grogol Utara 03 yang dengan suka rela ingin ikut serta berbakti sosial. Penggalangan bahan sembako yang dilakukan selama 2 hari, dengan luar biasanya menciptakan tumpukan 95 bungkus teh kotak, mie instan 347 bungkus, gula pasir 80 kg, susu kental manis 88 pouch. Ada juga sumbangan berupa beras sebanyak 140 liter dan minyak goreng sebanyak 110 liter. Perlu diketahui, banyak peserta didik yang menyumbangkan lebih dari ukuran yang diharapkan, misalnya saja minyak goreng. Awalnya kami merekomendasikan ukuran ½ liter, tapi banyak sekali peserta didik yang bahkan mengumpulkan dengan ukuran yang lebih besar. Bukan hanya pada minyak goreng saja, tapi juga pada beras dan gula pasir. The more you give, the more you receive. Kami kira itulah pelajaran hidup yang sedang mereka pegang.
Oleh karena adanya beragam ukuran, maka hal pertama yang kami lakukan adalah memilah bahan sembako sesuai ukurannya. Lalu kami membuat paket dengan ukuran – ukuran yang sama terlebih dahulu. Setelah itu barulah kami lakukan penyesuaian terhadap bahan sembako dengan ukuran yang berbeda. Sehingga isi setiap paket ada yang lengkap 6 macam sembako dan ada juga yang tidak lengkap. Namun sekalipun tidak lengkap, sebagai gantinya ukuran dari jenis sembako lainnya yang diberikan lebih besar agar jadi penyeimbang. Alhasil dari semua bahan sembako yang terkumpul, jadilah 140 kantong paket sembako. Yeay.. Alhamdulillah, tahun ini pun penggalangan sembako dapat melebihi target dimana target semula adalah 85 paket sembako.
- Upacara HUT Pramuka ke-63
Upacara berlangsung dengan khidmat. Diawali dengan persiapan pukul 06.30 dan akhirnya dapat dilaksanakan 15 menit lebih awal dari waktu yang ditentukan. Upacara dimulai pukul 06.45 dengan Bapak Darminto, M.Pd selaku Pembina upacara. Petugas upacara dihari itu adalah regu inti pramuka SDN Grogol Utara 03 yang sebelumnya sudah berlatih bersama kaka kaka pelatih pramuka diantaranya ka Yoga, ka Ibnu, Ka Shendy dan ka Jihan. Peserta upacara pagi itu adalah seluruh dewan guru dan peserta didik penggalang kelas 4, 5 dan 6. Amanat yang disampaikan oleh Pembina jika kita tarik kesimpulan adalah mengenai Gerakan pramuka yang sampai saat ini sudah melakukan banyak kegiatan dan upaya untuk menciptakan generasi emas tahun 2045. Dan titik awal untuk menciptakan sumber daya manusia yang baik adalah dari Fundamental Value Transformation Gerakan pramuka, yaitu Tri Satya dan Dasa Darma Pramuka. Yuk, SDN Grogol Utara 03 siap menjadi generasi emas!
- Pendistribusian bakti sosial
Pepatah mengatakan “Berbagi rezeki dengan tulus, berbakti kepada orang tua, berbuat baik kepada sesama, dapat mengubah duka menjadi bahagia dan menambah usia.” Hal inilah yang tergambar pada Rabu, 14 Agustus 2024 lalu. Rasa hangat, damai dan ikut berbahagia dengan dilaksanakannya menyaluran paket sembako bakti sosial kepada berbagai pihak. Semula kami menargetkan 45 warga kaum dhuafa dari RT 01 dan RT 02 RW 01 Kelurahan Grogol Utara, kecamatan Kebayoran Lama, Jakarta Selatan, sekaligus peserta didik yatim piatu SDN Grogol Utara 03 yang berjumlah 40 orang. Lagi lagi dengan mengucap hamdallah, SDN Grogol Utara dapat membagikan paket sembakonya lebih dari target sasaran. Kini telah diserahkan 45 paket pada kaum dhuafa RT 01 dan Rt 02, 40 paket untuk peserta didik ayatim piatu, 2 paket untuk pedagang di kantin SDN Grogol Utaara, 5 paket untuk tendik SDN Grogol Utara 03, 4 paket untuk kaka pelatih, 22 paket untuk pedagang di sekitar sekolah, dan 22 paket untuk kaum dhuafa di sekitar guru SDN Grogol Utara 03.
Ketua ketua RW 01 mengutarakan rasa bangga dan terima kasihnya untuk SDN Grogol Utara 03 atas adanya kegiatan bakti sosial ini. Beliau senang karena merasa bahwa ternyata pramuka bergerak aktif, ada di tengah- tengah masyarakat dan dapat memberikan dampak baik untuk masyarakat sekitar. Semoga agenda baik ini bisa terus berjalan di SDN Grogol Utara 03.
- Lomba Yel – yel
Sekolah kita memiliki lahan yang terbatas dibandingkan dengan jumlah seluruh peserta didik. Sehingga dihari itu kami membagi kegiatan menjadi 2 sesi. Dimana sesi 1 adalah penggalang dengan kegiatannya yaitu upacara, simbolisasi penyerahan bakti sosial dan juga lomba yel – yel per kelas. Untuk sesi 2 yaitu peserta didik siaga dengan kegiatannya yaitu pembukaan acara, simbolisasi penyerahan bakti sosial pada peserta didik yatim piatu dan juga lomba mewarnai.
Riuh tepuk tangan, suara lantang dan juga hentakan tongkat pramuka sudah terdengar disana sini sebelum upacara dimulai. Ternyata peserta didik penggalang sedang antusias antusiasnya berlatih yel yel kelas yang akan ditampilkan. Tak sia – sia, begitu sesi lomba yel – yel dimulai, tampilan mereka keren dan menarik. Tiap kelas menampilkan sesuatu yang dapat menarik perhatian juri dan juga penonton. Tak hanya bermodalkan suara tetapi juga formasi barisan dan atraksi yang patut diacungi jempol karena hanya dalam waktu 4 hari, mereka dapat menampilkannya dengan baik. Salut!
Berikut adalah daftar pemenang lomba yel – yel. Selamat!
Kelas 4 | |
Juara 1 | 4 C |
Juara 2 | 4 A |
Juara 3 | 4 B |
Kelas 5 | |
Juara 1 | 5 A |
Juara 2 | 5 B |
Juara 3 | 5 C |
Kelas 6 | |
Juara 1 | 6 E |
Juara 2 | 6 B |
Juara 3 | 6 F |
- Lomba Mewarnai
Pergantian sesi dimulai pukul 09.30. peserta penggalang dipersilahkan meninggalkan area sekolah dan peserta didik siaga mulai disiapkan berbaris dilapangan. Nah.. sesi ini yang menjadi tantangan karena cuaca yang semakin siang semakin panas. Karena satu dan lain hal, konsep acara pun sempat mengalami perubahan. Dimana seharusnya setelah peserta didik melakukan pembukaan acara dan penyerahan bakti sosial pada yatim piatu SDN Grogol Utara 03, diarahkan ke koridor – koridor kelas untuk mewarnai gambar. Namun pada akhirnya peserta didik mewarnai di lapangan dan koridor lantai 1 saja. Ditemani dengan alunan lagu pramuka dan lagu lagu anak, peserta didik dengan riang menggoreskan alat mewarnainya sambil ikut menyanyikan lagu yang berputar.
Semakin siang matahari semakin naik dan lapangan semakin penuh dengan terpaan sinarnya yang kian menyilaukan dan tentunya terasa panas. Berangsur angsur kami pindahkan peserta didik di lapangan ke tempat yang teduh. Walaupun begitu, tetap saja ada peserta didik yang entah mengapa tetap tidak mau pindah dan memilih bertahan dibawah sinar matahari. Yasudah, kita turuti sampai ia mencapai batas kesanggupannya sendiri. Totalitas!
Selamat kepada adik – adik yang gambarnya terpilih menjadi juara!
Kelas 1 | |
Juara 1 | Safira (1D) |
Juara 2 | Nuril (1B) |
Juara 3 | Azka (1D) |
Kelas 2 | |
Juara 1 | Azzahra (2D) |
Juara 2 | Raisha (2D) |
Juara 3 | Adiba (2A) |
Kelas 3 | |
Juara 1 | A. Nailah (3D) |
Juara 2 | Salsabila (3A) |
Juara 3 | Fairil (3B) |
Baiklah, itu tadi rangkuman informasi yang bisa disampaikan mengenai kegiatan Peringatan HUT Pramuka ke – 63. Semoga kegiatan ini dapat meninggalkan kesan yang bermakna bagi kita semua.
Kami ucapkan terima kasih yang sebesar-besarnya kepada ibu Sri Surjani, S.Pd selaku pelindung kegiatan ini. Terima kasih kepada ibu Tati Sumiati, S.Pd dan bapak Ridho Gilang Amukti, M.Pd selaku penasehat. Terima kasih kepada dewan guru beserta staff SDN Grogol Utara 03. Terima kasih kepada ketua beserta jajaran komite SDN Grogol Utara 03 yang telah mendukung kegiatan ini. Terima kasih kepada kaka kaka pelatih pramuka atas kerjasamanya. Terima kasih kepada para kordinator ekskul pramuka atas upayanya dalam menyelenggarakan kegiatan. Dan tentunya, terima kasih kepada seluruh peserta didik SDN Grogol Utara 03 beserta orang tua murid, yang tanpa partisipasinya, kegiatan ini tidak akan dapat terlaksana.
Semoga kegiatan ini menjadi amalan baik untuk kita semua.
Terima kasih dan Salam Pramuka!
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Side Effects Of Ipamorelin In Growth Hormone Release And Anti-Aging Research
Side Effects of Ipamorelin in Growth Hormone Release and Anti-Aging Research
Ipamorelin has become popular among researchers studying growth
hormone (GH) dynamics and anti‑aging strategies.
While its efficacy in stimulating GH secretion is
well documented, a thorough understanding of its side effect profile—especially when used at higher doses or over extended periods—is essential for safe clinical translation.
—
What is Ipamorelin?
Ipamorelin is a synthetic peptide belonging to the class of growth hormone‑releasing peptides (GHRPs).
It was developed in the late 1990s as part of an effort to produce selective, non‑agonistic stimulators of
GH release. Unlike older GHRPs that activate multiple receptors
and pathways, ipamorelin is engineered for higher selectivity toward the ghrelin receptor.
—
Chemical Nature and Classification
Molecular Formula: C₁₆H₂₇N₅O₄
Structure: A hexapeptide (Glu‑Leu‑His‑Pro‑Gly‑Trp) with a cyclic
constraint at the N‑terminus.
Classification: Peptidomimetic GHRP, ghrelin receptor agonist.
Its peptide backbone confers high water solubility and allows
for subcutaneous or intranasal administration in experimental settings.
Mechanism of Action in Growth Hormone Release
Ipamorelin binds to the growth hormone secretagogue receptor (GHS‑R1a) on pituitary somatotrophs.
This binding mimics endogenous ghrelin, triggering a cascade that increases cyclic AMP and calcium influx.
The result is transient but robust GH secretion without significant prolactin or oxytocin elevation.
—
Role in Anti-Aging and Regenerative Medicine
Researchers hypothesize that chronic modest increases in circulating GH can:
Enhance cellular repair mechanisms.
Promote telomere maintenance.
Modulate inflammatory pathways implicated in age‑related decline.
Ipamorelin’s selective action is believed to reduce off‑target effects, making it attractive for long‑term anti‑aging protocols.
General Benefits of Ipamorelin in Research
Muscle Growth and Repair
Studies show increased lean mass and improved recovery after exercise when ipamorelin is paired with resistance training.
GH stimulates satellite cell activation and protein synthesis.
Fat Metabolism and Body Composition
GH promotes lipolysis, especially in visceral fat depots. Short‑term
trials report modest reductions in waist circumference and improvements in insulin sensitivity.
Longevity and Anti-Aging Hypotheses
Preclinical data suggest that sustained GH stimulation can extend lifespan in rodent models by enhancing autophagy and reducing
oxidative damage. Translational work is ongoing to verify
these effects in humans.
—
Side Effects of Ipamorelin in Growth Hormone Release
Commonly Reported Short‑Term Side Effects
Injection site pain or irritation.
Mild edema or transient fluid retention.
Occasional headaches.
Minor nausea or gastrointestinal discomfort.
These are generally dose‑dependent and resolve with tapering or supportive care.
Hormonal and Metabolic Concerns
Elevated GH can stimulate insulin‑like growth factor 1
(IGF‑1), potentially altering glucose metabolism.
In susceptible individuals, this may precipitate transient hyperglycemia or impaired fasting
glucose.
Long‑Term and High‑Dose Use Risks
Acromegaly‑like changes: Excessive GH exposure over months
can lead to soft tissue swelling and joint discomfort.
Hypertension: Fluid retention may raise blood pressure in predisposed
patients.
Cancer Risk: While evidence is inconclusive, chronic IGF‑1 elevation has been linked to increased proliferation of certain cell lines.
Side Effects of Ipamorelin in Anti-Aging Research
Age‑Related Sensitivities
Older adults may exhibit heightened sensitivity to GH‑induced fluid shifts and metabolic alterations.
Monitoring of weight, blood pressure, and glucose levels is essential.
Interactions with Other Hormonal Therapies
When combined with testosterone or thyroid hormone replacement,
additive effects on metabolism can occur, necessitating
careful dose adjustment and endocrine profiling.
Psychological and Neurological Effects
Some users report mood swings or mild anxiety during high‑dose regimens.
These are likely secondary to hormonal fluctuations rather than direct neurotoxicity.
—
Comparative Safety – Ipamorelin vs Other GHRPs
Ipamorelin vs GHRP‑2 and GHRP‑6
GHRP‑2/6 stimulate GH but also increase prolactin, oxytocin, and appetite.
Ipamorelin’s minimal effect on these hormones results in a cleaner side‑effect profile.
cjc ipamorelin side effects reddit vs Sermorelin
Sermorelin is an endogenous ghrelin analogue that requires frequent dosing to maintain GH levels.
It can cause more pronounced injection site reactions and has a shorter half‑life, leading to greater variability
in hormone release.
—
Why Ipamorelin Is Often Considered “Milder”
Its high receptor specificity reduces collateral activation of other
neuroendocrine pathways. The peptide’s short half‑life limits
systemic exposure, and its low affinity for prolactin/oxytocin receptors minimizes unwanted hormonal cross‑talk.
—
Risk Mitigation Strategies in Research Use
Proper Dosage Considerations
Standard research protocols employ 100–200 µg per injection twice daily.
Dosing should be individualized based on baseline GH/IGF‑1 levels and body weight.
Monitoring Protocols
Baseline and periodic fasting glucose.
IGF‑1 and GH profiles.
Blood pressure, heart rate, and anthropometric measurements.
Liver function tests if combined with hepatotoxic agents.
Lifestyle Factors That Influence Side Effects
Adequate hydration reduces edema risk. Balanced
carbohydrate intake helps mitigate transient hyperglycemia.
Regular exercise can counteract fluid retention and improve insulin sensitivity.
—
Legal, Ethical, and Clinical Perspectives
Regulatory Status of Ipamorelin
In most jurisdictions, ipamorelin is classified as a research chemical with no approved medical indication. Off‑label
use for anti‑aging purposes remains unregulated and
carries legal uncertainties.
Ethical Concerns in Anti-Aging Clinics
The absence of robust clinical trials raises questions about informed consent, long‑term
safety, and the potential exploitation of vulnerable populations
seeking longevity interventions.
Importance of Clinical Supervision
Any application beyond controlled research settings should involve endocrinology oversight, comprehensive
patient education, and adherence to institutional review board guidelines.
—
Future Directions in Ipamorelin Research
Expanding Human Trials: Large‑scale, randomized, placebo‑controlled studies are needed to confirm efficacy and safety.
Potential for Safer Peptide Derivatives: Structural modifications could further reduce side
effects while preserving GH release potency.
Role in Precision Anti‑Aging Medicine: Personalized dosing algorithms based on genetic markers (e.g.,
GH receptor polymorphisms) may optimize therapeutic outcomes.
Conclusion
Ipamorelin offers a promising, relatively mild approach to stimulate growth hormone secretion for research
into anti‑aging and regenerative therapies. Its side effect profile is comparatively favorable against other GHRPs,
yet careful dose management, monitoring, and ethical oversight remain critical.
As the field evolves, rigorous clinical trials will determine whether ipamorelin can safely transition from a
laboratory tool to a mainstream anti‑aging intervention.
—
Anabolic Steroid Wikipedia
Below is a structured “cheat‑sheet” that covers the most common concepts, models, and techniques you’ll encounter
in an introductory machine‑learning class.
The list is organized by theme so you can quickly locate a
particular topic or see how ideas fit together.
—
1️⃣ Machine Learning Fundamentals
Concept Quick Note
Supervised vs Unsupervised Supervised learns
from labeled pairs \((x,y)\); unsupervised discovers
structure in unlabeled data.
Training / Validation / Test Sets Split data to avoid over‑fitting:
`train → fit model`, `validation → tune hyper‑params`, `test
→ final performance`.
Cross‑Validation (k‑fold) Repeatedly train on \(k-1\) folds,
validate on the remaining fold; average metrics.
Bias–Variance Tradeoff High bias: under‑fitting; high variance: over‑fitting.
Regularization shifts balance toward lower variance.
Loss Functions Choose based on task: MSE for regression, cross‑entropy for classification.
Metrics Accuracy, precision/recall/F1 for classification; MAE/MSE/RMSE for regression.
Hyperparameters vs Parameters Hyperparameters (e.g., learning rate, number of layers) are set before training; parameters (weights) are learned during training.
—
5. Practical Recommendations
Scenario Recommended Strategy
Limited labeled data, high complexity model Use transfer learning + data augmentation + early
stopping.
Large dataset, risk of overfitting Increase dropout/weight decay, consider deeper network with batch norm.
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Model interpretability needed Prefer simpler architectures
or incorporate attention mechanisms; use LIME/SHAP for post‑hoc explanations.
—
6. Summary
Key hyperparameters: learning rate, weight decay, dropout,
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Optimization strategies: Adam/WNAdam with warmup & cosine decay, gradient clipping,
early stopping.
Regularization techniques: Dropout, weight decay, data
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Evaluation and monitoring: Use robust validation metrics, monitor loss curves,
implement learning rate schedulers, perform systematic hyperparameter sweeps.
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After taking Anavar for two weeks, many users begin to notice subtle yet encouraging changes in their physique
and overall well‑being. The steroid’s mild nature allows for a relatively gentle introduction into the world of
performance enhancement, making it popular among those who want to see tangible results without drastic side effects.
Anavar Results After 2 Weeks: What to Expect
In the first fortnight of Anavar usage, you may experience an increase in muscle firmness
and slight definition. Because Anavar promotes nitrogen retention and
protein synthesis, even a short period can lead to a noticeable tightening
of existing muscle fibers. Some users report a reduction in body fat percentage
as the drug aids in preserving lean mass while dieting or training.
This initial phase often feels like a “spring boost” – you feel more
energetic during workouts, and your recovery times may shorten.
The hormonal changes that occur within two weeks can also influence mood and confidence
levels. Many individuals note an uplifted sense of well‑being, which is partly
attributed to Anavar’s mild anabolic effects on the central nervous system.
While dramatic transformations are unlikely in just 14 days, the foundation for longer‑term progress becomes
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Lean Muscle Gain – Anavar encourages muscle growth without a
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Fat Loss Support – The steroid’s metabolism‑boosting properties help burn fat while
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Reduced Recovery Time – Users often experience faster healing of minor muscle strains or workout-induced soreness.
Improved Strength – Although the increase is modest compared to other anabolic
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Safety Tips
Start Low and Go Slow – If you are new to steroids or this is your first cycle, consider beginning at the lower end of the dosage range (5–10 mg per day for women).
This helps mitigate potential side effects.
Monitor Hormonal Balance – Anavar can suppress natural testosterone production. Discuss with a healthcare professional how to
manage post‑cycle therapy if needed.
Track Blood Work – Regular liver function tests
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